Aberrant salience network functional connectivity in auditory verbal hallucinations: a first episode psychosis sample
Translational Psychiatry March 27, 2018 P. Mallikarjun, P. Lalousis, T. Dunne et al.
Auditory verbal hallucinations (AVH) are linked to altered connectivity between brain networks involved in salience, internal thought, and sensory processing. In patients experiencing their first episode of psychosis, those with AVH showed increased resting-state functional connectivity between the salience network and the default mode network, and between the salience network and the cerebellum, but reduced connectivity between the claustrum and the insula, compared to healthy controls. These patterns may reflect impaired appraisal of internal activity and compensatory overactivity in auditory and memory networks, contributing to the generation and individual content of hallucinations.