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M. Broome

2 papers in the library · publishing 2018-2022

Papers

Subjective experience and meaning of delusions in psychosis: a systematic review and qualitative evidence synthesis.

Lancet Psychiatry May 1, 2022 R. Ritunnano, Joshua J. Kleinman, Danniella Whyte Oshodi et al.

Delusions in psychosis are best understood as highly individual and complex phenomena arising from a dynamic interplay of biological, personal, social, and cultural processes. A systematic review and qualitative synthesis of 24 studies representing 373 help-seeking individuals with psychosis identified three key themes: a radical shift in the lived world dominated by intense emotions; a process of doubting, losing, and rediscovering oneself within delusional realities; and a search for meaning, belonging, and coherence beyond mere dysfunction. The findings propose an Emergence Model of Delusion, suggesting that effective clinical care should account for the subjective experience and meaning of delusions, which may also address power imbalances and epistemic injustices in mental health.

DOI: 10.1016/s2215-0366(22)00104-3 (opens in new tab) Full text (opens in new tab) Medicine Psychology

Aberrant salience network functional connectivity in auditory verbal hallucinations: a first episode psychosis sample

Translational Psychiatry March 27, 2018 P. Mallikarjun, P. Lalousis, T. Dunne et al.

Auditory verbal hallucinations (AVH) are linked to altered connectivity between brain networks involved in salience, internal thought, and sensory processing. In patients experiencing their first episode of psychosis, those with AVH showed increased resting-state functional connectivity between the salience network and the default mode network, and between the salience network and the cerebellum, but reduced connectivity between the claustrum and the insula, compared to healthy controls. These patterns may reflect impaired appraisal of internal activity and compensatory overactivity in auditory and memory networks, contributing to the generation and individual content of hallucinations.

DOI: 10.1038/s41398-018-0118-6 (opens in new tab) Full text (opens in new tab) Medicine Psychology