Functional Neuroimaging in Dissociative Disorders: A Systematic Review.
Journal of Personalized Medicine August 29, 2022 Martina Nicole Modesti, Ludovica Rapisarda, Gabriela Capriotti et al.
Dissociative disorders involve disruptions in memory, consciousness, perception, motor control, and identity. This systematic review of 13 functional neuroimaging studies, conducted on 51 patients with dissociative identity disorder (DID), 28 with depersonalization disorder, 24 with dissociative amnesia, and 6 with other or unspecified dissociative disorders, identifies common brain activation patterns. Prefrontal cortex dysfunction appears prominent across these disorders. In DID, changes in the caudate's neural network relate to altered identity states, and dysfunction of the anterior cingulate gyrus also plays a role. Other affected regions include parietal, temporal, and insular cortices, along with subcortical areas. Further research is needed to clarify neurofunctional correlates for better tailored treatments.