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Lauri Laaksonen

2 papers in the library · publishing 2021-2023

Papers

Decreased Thalamic Activity Is a Correlate for Disconnectedness during Anesthesia with Propofol, Dexmedetomidine and Sevoflurane But Not S-Ketamine.

The Journal of neuroscience : the official journal of the Society for Neuroscience June 28, 2023 Oskari Kantonen, Lauri Laaksonen, Michael Alkire et al.

Anesthesia-induced disconnectedness—unresponsiveness and unawareness of external events—is linked to reduced activity in the thalamus, but not to widespread cortical suppression, which instead reflects drug exposure itself. In a study of 160 healthy men, four anesthetics (propofol, dexmedetomidine, sevoflurane, S-ketamine) or saline placebo were administered at doses designed to make half of subjects unresponsive. Positron emission tomography showed that, for all anesthetics except S-ketamine, lower thalamic metabolic activity distinguished disconnected from connected states. Widespread cortical metabolic suppression occurred in both connected and disconnected subjects compared with placebo, indicating it is necessary but insufficient for loss of consciousness.

DOI: 10.1523/jneurosci.2339-22.2023 (opens in new tab) Full text (opens in new tab) Anesthesia Consciousness Disconnected Neuroimaging +1

On no man's land: Subjective experiences during unresponsive and responsive sedative states induced by four different anesthetic agents.

Consciousness and Cognition November 1, 2021 Linda Radek, Lauri Koskinen, Nils Sandman et al.

Subjective experiences, most often dreaming or incorporating elements of the setting, are common during sedation with anesthetics that act through different molecular mechanisms. In healthy male participants given equisedative doses of dexmedetomidine, propofol, sevoflurane, or S-ketamine for one hour, 46.9% of those who were arousable reported experiences. Dexmedetomidine was associated with the most frequent reports, while S-ketamine produced the most multimodal experiences. Whether participants were responsive at the end of administration did not affect the prevalence or content of the experiences. The differences between drugs were small in this sample.

DOI: 10.1016/j.concog.2021.103239 (opens in new tab) Full text (opens in new tab) Dreaming Ketamine Anesthesia Awareness +6