Effectiveness of pharmacological and non-pharmacological interventions for treatment-resistant depression in older patients: a systematic review and meta-analysis.
BMJ mental health March 3, 2025 Alice Jane Larsen, Giulia Teobaldi, Rosario Isabel Espinoza Jeraldo et al. 10 citations
Depression in older adults is often undertreated. A 2011 systematic review of treatments for treatment-resistant depression (TRD) in older adults identified one placebo-controlled randomised controlled trial (RCT). We aimed to update this review, synthesising evidence for the effectiveness of treatments for TRD in older people. We systematically searched electronic databases (PubMed, Cochrane,...
DOI: 10.1136/bmjment-2024-301324 (opens in new tab)
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Treatment-resistant depression
Adult psychiatry
Depression treatment
Geriatric psychiatry
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