APOE ε4-related structural vulnerability in mild cognitive impairment: a subsystem-based analysis of the default mode network.
Research Square May 11, 2026 Xiaoming Yang, Jian Lyu, Jubo Wang et al.
Mild cognitive impairment (MCI) is a critical prodromal stage of progressive cognitive decline. As a core cognitive brain network, the default mode network (DMN) exhibits structural alterations in MCI that are closely associated with cognitive impairment. Apolipoprotein E ε4 (APOE ε4), the strongest genetic risk factor for pathological cognitive decline, has been shown to disrupt the structural...