When pain becomes self: limbic-default mode network hyperconnectivity predicts microvascular decompression failure in trigeminal neuralgia.
Brain Communications 2026 Ying Wang, Chenglong Cao, Hao Chen et al.
Microvascular decompression is the standard surgical intervention for classical trigeminal neuralgia attributed to NVC. However, up to 30% of patients experience poor outcomes despite technically successful surgery, suggesting non-peripheral mechanisms. This study investigates whether central neural reorganization-manifested as altered cortico-subcortical connectivity and white matter...