Mapping neural effects of mindfulness-based cognitive therapy in ADHD using EEG microstates and machine learning models.
Frontiers in Psychiatry January 1, 2025 Reza Meynaghizadeh Zargar, Sevket Hepark, Poppy L A Schoenberg
Mindfulness-based cognitive therapy (MBCT) reshapes resting-state brain network dynamics in adults with ADHD, as measured by EEG microstates. After a 12-week MBCT program, participants showed increased coverage and duration of microstates A and B, along with changes in microstate A (theta band) and microstate D (alpha band). These neural changes correlated with improvements in ADHD symptoms, mindfulness, quality of life, and executive function. Machine learning models using pre-treatment microstate dynamics predicted individual treatment response with 83% accuracy, suggesting that EEG biomarkers could help personalize mindfulness-based interventions for ADHD.