Development and effectiveness of a mindfulness-based cognitive therapy for individuals with spinal cord injury: Changes in quality of life and inflammatory biomarkers.
The journal of spinal cord medicine June 4, 2026 Chan-Woo Yeom, Onyoo Kim, Jeong-A Yu et al.
A tailored 4-week Mindfulness-Based Cognitive Therapy (MBCT) program for adults with spinal cord injury in a Korean rehabilitation hospital may improve spiritual well-being and inflammatory profiles, especially among those with lower baseline depression. The non-randomized controlled trial assigned 51 inpatients to MBCT or treatment-as-usual. No significant overall differences in quality of life or spiritual well-being were found between groups over time, but a significant group effect for spiritual well-being emerged. Among participants with normal-to-mild depression, significant interactions were observed. Biomarker analyses showed increased IL-10, decreased sTNFR2, and lower CRP levels in the MBCT group, suggesting reduced inflammation. Further randomized trials are needed.