Transcriptional profiles of antidepressant resistance across the corticolimbic pathway of chronically stressed mice.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology June 1, 2026 Trevonn M Gyles, Eric M Parise, Molly S Estill et al.
Treatment-resistant depression (TRD), defined by unsuccessful response to multiple antidepressants, affects approximately one-third of individuals with major depressive disorder, yet its underlying molecular mechanisms remain poorly understood. Here, we developed a preclinical model of TRD in which mice exposed to chronic social defeat stress were sequentially treated with fluoxetine (FLX) and...