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Sean P Madden

2 papers in the library · publishing 2022-2026

Papers

The time Collapse-Entrapment model of depersonalization severity.

Psychiatry Research June 9, 2026 Sean P Madden, Mark R Serper

Depersonalization involves feeling detached from one's own thoughts, body, and emotions. The Time Collapse-Entrapment Model proposes that temporal blurring—a subjective blending of past, present, and future—and reduced ability to vividly imagine one's future self increase perceived entrapment, which in turn predicts greater depersonalization severity. In 433 adults (79 with clinically significant depersonalization), those with severe symptoms reported higher psychological distress, absorption, cognitive fusion, entrapment, and temporal blurring, and lower future self-continuity. Discriminant function analysis correctly classified 75.6% of cases. Mediation analyses showed that temporal blurring and reduced vividness of the future self predicted depersonalization severity through perceived entrapment. Targeting temporal and self-continuity disturbances may be a clinically relevant intervention.

Smoked Cannabis Effects in Cannabis Users at Clinical High-Risk for Psychosis: A Further Investigation of Cognition and Reward

Cannabis February 22, 2022 Sean P Madden, John G Keilp, Olivia Wu et al.

Cannabis acutely worsened cognitive control and produced more aversive intoxication in cannabis users at clinical high-risk for psychosis, but not in psychiatrically-healthy cannabis users. Six high-risk and six healthy users smoked either active (5.5% THC) or placebo cannabis under double-blind conditions. High-risk participants showed decreased response inhibition and aversive intoxication after active cannabis, along with changes in psychomotor speed and cannabis-related attentional bias. No such effects appeared in healthy users. The findings provide preliminary evidence of a deleterious cognitive and reward-related response to cannabis in individuals with preexisting psychosis risk.