Jack M Ognibene

Chronic exposure to inhaled vaporized cannabis high in Δ9-THC suppresses Adderall-induced brain activity.

Frontiers in Pharmacology 2024 Jack M Ognibene, Rajeev I Desai, Praveen P Kulkarni et al.

There are increasing reports of the misuse of prescription psychostimulants for cognitive enhancement together with recreational cannabis. This raises a concern that chronic use of cannabis high in Δ9-THC may alter the sensitivity to amphetamines. In this exploratory study we hypothesized chronic exposure to Δ9-THC through vaporized cannabis would diminish the central nervous system (CNS)...