Longevity Horizon
January 12, 2026
Jaba Tkemaladze
5 citations
The brain may implement the same computational principle as the double-slit experiment, using superposition and interference to maintain multiple hypotheses and environment-driven localization to collapse them into a single perception. This framework, called Ze, reinterprets sleep as a quantum eraser that restores cognitive flexibility. It links quantum decoherence, Bayesian inference, and sleep-wake neurobiology, offering a transdiagnostic model for psychopathology where disorders like psychosis and PTSD involve dysregulation of this cycle. The authors argue that the brain instantiates the core logic of the double-slit experiment as a continuous process of resolving ambiguity.
Longevity Horizon
January 11, 2026
Jaba Tkemaladze
5 citations
Consciousness is a process of selection, collapsing potential states into a single coherent narrative. The Ze formalism models this with a cognitive localization parameter, Γ_Ze. Wakefulness (Γ_Ze ≫ 1) involves rapid collapse for stable, logical thought. Sleep (Γ_Ze → 0) suspends this localization, allowing the brain to maintain superpositions of memory and meaning, with dreams arising from interference patterns. Psychedelics reduce Γ_Ze consciously, anesthesia nullifies it artificially, and schizophrenia involves its dysregulation. Sleep's primary function is offline recalibration of cognitive probability amplitudes, aiding memory integration, emotional regulation, and creative insight. The framework redefines sleep as an active operation for cognitive flexibility and waking consciousness.
Longevity Horizon
January 15, 2026
Jaba Tkemaladze
4 citations
The measurement problem in quantum mechanics is addressed through a new framework called Ze, which combines Relational Quantum Mechanics with the Active Inference paradigm from neuroscience. Quantum states are described as relational, defined by the posterior beliefs of interacting generative models that minimize variational free energy. Superposition is formalized as high compatibility between competing models with low free-energy conflict, while collapse is reconceived as an optimization-driven phase transition when model conflict exceeds a critical threshold. Matter-wave interferometry with complex molecules provides an experimental testbed, and analogous transitions in human cognition—from wakefulness to dreaming and psychedelic states—are proposed to follow similar principles.
Preprints.org
January 13, 2026
Jaba Tkemaladze
3 citations
preprint
The brain may operate like a biological version of the double-slit experiment, maintaining multiple possible interpretations of reality in a state of active interference, analogous to quantum superposition. Sensory input, actions, and social context act as 'which-path' information that collapses this ambiguity into a single, coherent perception and decision. Sleep functions as a periodic quantum eraser, degrading this which-path information to restore cognitive flexibility and prevent rigid, maladaptive thinking. This framework links quantum decoherence, Bayesian inference, and sleep neurobiology, offering a model for disorders like psychosis and PTSD as dysregulations of this interference-localization cycle. The brain does not merely observe quantum reality but instantiates its core logic as a continuous process of resolving ambiguity.
Longevity Horizon
April 9, 2026
Jaba Tkemaladze
2 citations
Dreaming is a complex cognitive process predominantly linked to REM sleep. This theoretical review proposes that higher levels of sex hormones, specifically testosterone and estrogen, are associated with increased REM sleep activity, which in turn correlates with more frequent and vivid dream recall. Testosterone may enhance REM sleep through dopaminergic modulation, while estrogen may do so via cholinergic and GABAergic mechanisms. Evidence from hormone administration studies, menstrual cycle phases, and menopause supports these associations. The age-related decline in sex hormones parallels reduced REM density and dream recall, suggesting a link with cognitive aging. The framework positions dream recall frequency as a potential indicator of neuroendocrine health, and the authors propose a causal model with three testable predictions.