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A. Owen

3 papers in the library · publishing 2019-2022

Papers

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Whole-brain modelling identifies distinct but convergent paths to unconsciousness in anaesthesia and disorders of consciousness

Communications Biology April 20, 2022 Andrea I. Luppi, Pedro A. M. Mediano, Fernando E. Rosas et al.

The human brain entertains rich spatiotemporal dynamics, which are drastically reconfigured when consciousness is lost due to anaesthesia or disorders of consciousness (DOC). Here, we sought to identify the neurobiological mechanisms that explain how transient pharmacological intervention and chronic neuroanatomical injury can lead to common reconfigurations of neural activity. We developed and...

Consciousness-specific dynamic interactions of brain integration and functional diversity

Nature Communications October 10, 2019 Andrea I. Luppi, Michael M. Craig, Ioannis Pappas et al.

Prominent theories of consciousness emphasise different aspects of neurobiology, such as the integration and diversity of information processing within the brain. Here, we combine graph theory and dynamic functional connectivity to compare resting-state functional MRI data from awake volunteers, propofol-anaesthetised volunteers, and patients with disorders of consciousness, in order to...

Opportunities and challenges for a maturing science of consciousness

Nature Human Behaviour February 1, 2019 M. Michel, Diane M Beck, Ned Block et al.

Scientific research on consciousness is critical to multiple scientific, clinical, and ethical issues. The growth of the field could also be beneficial to several areas including neurology and mental health research. To achieve this goal, we need to set funding priorities carefully and address problems such as job creation and potential media misrepresentation.