Circuit State–Experience Coupling: A Framework for Durable Psychological Change in Psychiatry
Preprints.org June 17, 2026 Daniel Holguin preprint
Four clinical literatures — psychedelic-assisted therapy, accelerated transcranial magnetic stimulation, closed-loop deep brain stimulation, and reconsolidation-based trauma therapy — produce durable change from brief, often single, interventions in conditions the current standard of care has not solved. The convergence is not procedural. Each modality transiently induces a high-plasticity...