Psychedelic Therapy vs Antidepressants for the Treatment of Depression Under Equal Unblinding Conditions
JAMA Psychiatry March 18, 2026 Zachary J. Williams, Hannah Barnett, Balázs Szigeti 10 citations
Importance: Psychedelic-assisted therapy (PAT) trials have high levels of functional unblinding, which biases results when comparing PAT with blinded interventions. Because PAT is effectively always open label, treatment results should be compared with those of open-label traditional antidepressants (TADs), so potential benefits associated with patients knowing their treatment is equal between...