Psychedelics do not always enhance cognitive flexibility: The potential role of time-varying effects on reward learning processes
Neuroscience & Biobehavioral Reviews May 30, 2026 Raquel Kosted, Manoj K. Doss, Jennifer J. Donegan et al. 1 citation
Although research on psychedelics (hallucinogenic serotonin 2 A or 5-HT2A agonists) has shown initial promise in ameliorating a range of psychiatric conditions, the mechanisms by which psychedelics promote therapeutic benefits have yet to be elucidated. Researchers have posited enhancements in cognitive flexibility as a transdiagnostic mechanism through which psychedelics could disrupt...
DOI: 10.1016/j.neubiorev.2026.106788 (opens in new tab)
Full text (opens in new tab)
Cognition
Reward system
Animal learning
Perception
+2