Y Kawashima

2 papers in the library · publishing 1995-1996

Papers

The effects of acute phencyclidine treatment on neuropeptide Y (NPY) neuronal system in the rat arcuate nucleus studied by immunocytochemistry and in situ hybridization.

Journal of neural transmission (Vienna, Austria : 1996) January 1, 1996 K Fukui, Y Kawashima, H Iizumi et al.

Acute treatment with the dissociative drug phencyclidine (PCP) increased the expression of neuropeptide Y (NPY) in the arcuate nucleus of the rat hypothalamus. NPY-immunoreactive cell bodies appeared in treated rats but not in controls, and NPY mRNA signals were higher in treated animals. These findings suggest that glutamatergic neurons may partly regulate the NPY system in this brain region.

DOI: 10.1007/bf01276415 Full text

Immunohistochemical alterations in neuropeptide Y-positive nerve elements in rat cerebral cortex following acute phencyclidine treatment.

Neuroreport March 7, 1995 K Fukui, Y Kawashima, H Iizumi et al.

Acute administration of phencyclidine (PCP), an NMDA receptor antagonist, alters neuropeptide Y (NPY) immunoreactivity in the rat forebrain. Compared to controls, PCP treatment increased the number of NPY-positive cell bodies by 178% while decreasing the area of NPY-positive fibers and terminals by 38%. These changes occurred throughout the cerebral cortex, suggesting that the cortical NPY neuronal system is at least partly regulated by glutamatergic inputs through NMDA receptor-mediated mechanisms.

DOI: 10.1097/00001756-199503000-00010 Full text