Clinical and sensorimotor gating effects of ketamine in normals.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology July 1, 2001 E J Duncan, S H Madonick, A Parwani et al.
The clinical similarities between PCP psychosis and schizophrenia have contributed importantly to the development of the glutamate hypothesis of schizophrenia. Sensory gating, as measured by prepulse inhibition of the acoustic startle reflex (PPI), is impaired in patients with schizophrenia. In animals, the noncompetitive NMDA antagonists PCP and ketamine disrupt PPI in a way that resembles the...