A Parwani

2 papers in the library · publishing 2001

Papers

Sort Most recent Most cited

Effects of ketamine in normal and schizophrenic volunteers.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology October 1, 2001 Adrienne C. Lahti, M A Weiler, B A Tamara Michaelidis et al.

This study evaluates the effects of ketamine on healthy and schizophrenic volunteers (SVs) in an effort to define the detailed behavioral effects of the drug in a psychosis model. We compared the effects of ketamine on normal and SVs to establish the comparability of their responses and the extent to which normal subjects might be used experimentally as a model. Eighteen normal volunteers (NVs)...

DOI: 10.1016/s0893-133x(01)00243-3 Full text

Clinical and sensorimotor gating effects of ketamine in normals.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology July 1, 2001 E J Duncan, S H Madonick, A Parwani et al.

The clinical similarities between PCP psychosis and schizophrenia have contributed importantly to the development of the glutamate hypothesis of schizophrenia. Sensory gating, as measured by prepulse inhibition of the acoustic startle reflex (PPI), is impaired in patients with schizophrenia. In animals, the noncompetitive NMDA antagonists PCP and ketamine disrupt PPI in a way that resembles the...

DOI: 10.1016/s0893-133x(00)00240-2 Full text