Phencyclidine Discoordinates Hippocampal Network Activity But Not Place Fields.
The Journal of neuroscience : the official journal of the Society for Neuroscience December 6, 2017 Hsin-Yi Kao, Dino Dvořák, Eunhye Park et al.
We used the psychotomimetic phencyclidine (PCP) to investigate the relationships among cognitive behavior, coordinated neural network function, and information processing within the hippocampus place cell system. We report in rats that PCP (5 mg/kg, i.p.) impairs a well learned, hippocampus-dependent place avoidance behavior in rats that requires cognitive control even when PCP is injected...