Blockade of phencyclidine-induced effects by a nitric oxide donor.
British Journal of Pharmacology July 1, 2000 M Bujas-Bobanovic, D C Bird, H A Robertson et al.
1. Phencyclidine (PCP) is widely used as an animal model of schizophrenia. The aim of this study was to better understand the role of nitric oxide (NO) in the mechanism of action of PCP and to determine whether positive NO modulators may provide a new approach to the treatment of schizophrenia. 2. The effects of the NO donor, sodium nitroprusside (SNP), were studied in PCP-treated rats....