Psychosis: pathological activation of limbic thalamocortical circuits by psychomimetics and schizophrenia?
Trends in Neurosciences June 1, 2001 F R Sharp, M Tomitaka, M Bernaudin et al.
Non-competitive NMDA receptor antagonists, such as phencyclidine, ketamine and MK801, produce psychosis in humans. These drugs also produce injury to cingulate-retrosplenial cortex in adult rodents that can be prevented by GABA-receptor agonists and antipsychotics such as haloperidol and clozapine. MK801 injections into anterior thalamus reproduce limbic cortex injury, and GABA-receptor agonist...