Spatial memory deficits induced by perinatal treatment of rats with PCP and reversal effect of D-serine.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology June 1, 2004 Janne Damm Andersen, Bruno Pouzet
It has been suggested that perinatal treatment with the noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist phencyclidine (PCP) induces transient neurodegeneration in the limbic and cortical structures of rats. Since dysfunction of these structures is associated with cognitive deficits in patients with schizophrenia, we studied the effects of subchronic treatment with PCP in...