Effects of repeated phencyclidine administration on adult hippocampal neurogenesis in the rat.
Synapse (New York, N.Y.) July 1, 2006 Juan Liu, Toshihito Suzuki, Tatsunori Seki et al.
Dysfunctional maturation of neural networks, particularly hippocampus-prefrontal networks, may be of particular interest in determining the pathophysiology of schizophrenia. Phencyclidine (PCP)-induced symptoms in humans appear to offer a more complete model of schizophrenia than do amphetamine-induced symptoms. This study investigated the effects of intermittent i.p. injections of PCP (7.5...