Antidepressants in the post-ketamine Era: Pharmacological approaches targeting the glutamatergic system.
Neuropharmacology February 1, 2023 Shigeyuki Chaki, Mai Watanabe
The efficacy of currently available medications for depression is unsatisfactory, and that has spurred the development of novel antidepressants based on a hypothesis other than the monoamine hypothesis. Recent studies have revealed the importance of the glutamatergic system as a drug target for depression, and the validity of this hypothesis has been underpinned by the discovery of the...