Dextromethorphan-bupropion combination in depression with dual diagnosis: Insights from a case series.
Indian Journal of Psychiatry February 1, 2026 Mahak Aggarwal, Jawahar Singh, Khushpreet Kaur et al.
Major depressive disorder and co-morbid substance use disorder represent a challenging dual diagnosis, characterized by persistent anhedonia, high relapse rates, and poor response to conventional antidepressants. The dextromethorphan-bupropion combination with synergistic glutamatergic and dopaminergic mechanisms provides a new treatment option. We present three male patients with alcohol or...