Nitrous Oxide (N2O) as a Treatment for Refractory Depression: A Word of Caution.
Journal of Clinical Psychopharmacology September 12, 2020 K. Fluegge
To the Editors: N agele et al 1 have suggested medical utility of nitrous oxide (N2O) for the management of treatment-resistant major depression disorder (trMDD). Their work described basic concepts in N2O administration for the lay psychiatrist as well as the compound's known pharmacology and potential risks from repeated exposure, including N2O-induced inactivation of cobalamin and folate...