Nitrous oxide causes peripheral neuropathy in a dose dependent manner among recreational users
Journal of Psychopharmacology February 1, 2020 Adam Winstock, J. Ferris
Background: Nitrous oxide (N2O) has been used in clinical and recreational settings for over 150 years. Through inactivation of the Vitamin B12 dependent enzyme, methionine synthase, N2O can lead to the development of peripheral neuropathy. This study sought to determine the relationship between the exposure and risk of neurological symptoms in the largest ever sample of users. Design: Data are...