Physiological basis underlying antidepressant-induced activation of TrkB receptors
bioRxiv August 31, 2021 Okko Alitalo, Samuel Kohtala, Marko Rosenholm et al. preprint
We show that both pharmacological and non-pharmacological treatments of depression activate TrkB receptors—a well-established target of antidepressants—by inducing a physiological response coupled to sedation. Several rapid-acting antidepressants trigger TrkB signaling by evoking a state associated with electroencephalographic slow-wave activity, behavioral immobility, reduced cerebral glucose...