Nitrous oxide for the treatment of depression: a systematic review and meta-analysis.
EBioMedicine December 1, 2025 Kiranpreet Gill, Angharad N De Cates, Chantelle Wiseman et al.
Depression remains a global public health challenge, prompting interest in translational targets which allow for more effective and rapidly acting interventions. Nitrous oxide (N2O), an N-methyl-d-aspartate receptor antagonist, has demonstrated potential as a rapid-acting antidepressant. This study synthesised existing data on the efficacy and safety of N2O in depressive disorders. We...