Nitrous oxide (N2O) is commonly used as a recreational drug, and the Dutch police have reported numerous traffic incidents related to its misuse. At the same time, the in vivo pharmacokinetics of N2O remain underexplored. In light of these facts, this study aimed to detect and quantify N2O in blood and saliva after inhalation exposure of a recreational dose. Consequently, a pilot in vivo study...
Nitrous oxide (N2O), colloquially known as laughing gas, is a common recreational drug of abuse. The gas is inhaled in its undiluted form from a party balloon. Its intoxicating effects are described as dissociative and euphoric, accompanied by ataxia, hypoxia, and attenuated consciousness. Therefore, the recreational use of N2O appears irreconcilable with operating a vehicle in road traffic....