Colm M P O'Tuathaigh

2 papers in the library · publishing 2010-2014

Papers

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Genetic dissection of the psychotomimetic effects of cannabinoid exposure.

Progress in neuro-psychopharmacology & biological psychiatry July 3, 2014 Colm M P O'Tuathaigh, Ilse Gantois, John L. Waddington

Cannabis use is an established risk factor for the development of schizophrenia and related psychotic disorders. Factors that may mediate susceptibility to the psychosis-inducing effects of cannabis include the age at onset of first cannabis use, genetic predisposition, as well as interaction with other environmental risk variables. Clinical and preclinical genetic studies provide increasing...

DOI: 10.1016/j.pnpbp.2013.11.002 Full text Cannabis Delta-9-tetrahydrocannabinol Dopamine Psychosis

Chronic adolescent exposure to Δ-9-tetrahydrocannabinol in COMT mutant mice: impact on psychosis-related and other phenotypes.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology October 2010 Colm M P O'Tuathaigh, Magdalena Hryniewiecka, Aine Behan et al.

Cannabis use confers a two-fold increase in the risk for psychosis, with adolescent use conferring even greater risk. A high-low activity catechol-O-methyltransferase (COMT) polymorphism may modulate the effects of adolescent Δ-9-tetrahydrocannabinol (THC) exposure on the risk for adult psychosis. Mice with knockout of the COMT gene were treated chronically with THC (4.0 and 8.0 mg/kg over 20...

DOI: 10.1038/npp.2010.100 Full text