Effects of ketamine enantiomers on morphine and THC subjective effects in rats.
Journal of psychopharmacology (Oxford, England) December 26, 2025 Natalia Malikowska‐racia, Joanna Gołębiowska, Katarzyna Starowicz et al.
Ketamine, known for its rapid-acting antidepressant effects, is often coadministered with other psychoactive drugs, including opioids and cannabinoids, in both clinical and recreational settings. We investigated whether ketamine (R-, S-, or racemic R, S-) isoforms alter the subjective effects of morphine or Δ9-tetrahydrocannabinol (THC) and whether the interoceptive effects of ketamine overlap...