Acute d-serine treatment produces antidepressant-like effects in rodents
The International Journal of Neuropsychopharmacology September 12, 2011 Oz Malkesman, Daniel Austin, Tyson Tragon et al. 91 citations
Research suggests that dysfunctional glutamatergic signalling may contribute to depression, a debilitating mood disorder affecting millions of individuals worldwide. Ketamine, a N-methyl-D-aspartate (NMDA) receptor antagonist, exerts rapid antidepressant effects in approximately 70% of patients. Glutamate evokes the release of D-serine from astrocytes and neurons, which then acts as a...