An investigation of amino-acid neurotransmitters as potential predictors of clinical improvement to ketamine in depression
The International Journal of Neuropsychopharmacology November 1, 2011 Giacomo Salvadore, Jan Willem van der Veen, Yan Zhang et al. 105 citations
Amino-acid neurotransmitter system dysfunction plays a major role in the pathophysiology of major depressive disorder (MDD). We used proton magnetic resonance spectroscopy (¹H-MRS) to investigate whether prefrontal levels of amino-acid neurotransmitters predict antidepressant response to a single intravenous infusion of the N-methyl-D-aspartate (NMDA) antagonist ketamine in MDD patients....