Concomitant BDNF and sleep slow wave changes indicate ketamine-induced plasticity in major depressive disorder
The International Journal of Neuropsychopharmacology June 7, 2012 Wallace C. Duncan, Simone Sarasso, Fabio Ferrarelli et al. 253 citations
The N-methyl-d-aspartate (NMDA) receptor antagonist ketamine has rapid antidepressant effects in treatment-resistant major depressive disorder (MDD). In rats, ketamine selectively increased electroencephalogram (EEG) slow wave activity (SWA) during non-rapid eye movement (REM) sleep and altered central brain-derived neurotrophic factor (BDNF) expression. Taken together, these findings suggest...