Atsushi Kasai

2 papers in the library · 91 citations · publishing 2014-2019

Papers

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(R)-Ketamine Induces a Greater Increase in Prefrontal 5-HT Release Than (S)-Ketamine and Ketamine Metabolites via an AMPA Receptor-Independent Mechanism

The International Journal of Neuropsychopharmacology July 16, 2019 Yukio Ago, Wataru Tanabe, Momoko Higuchi et al. 91 citations

BACKGROUND: Although recent studies provide insight into the molecular mechanisms of the effects of ketamine, the antidepressant mechanism of ketamine enantiomers and their metabolites is not fully understood. In view of the involvement of mechanisms other than the N-methyl-D-aspartate receptor in ketamine's action, we investigated the effects of (R)-ketamine, (S)-ketamine, (R)-norketamine...

DOI: 10.1093/ijnp/pyz041 Full text Ketamine Ampa receptor Mechanism biology Pharmacology +3

Increased behavioral and neuronal responses to a hallucinogenic drug in PACAP heterozygous mutant mice.

PLoS One 2014 Keisuke Hazama, Atsuko Hayata-Takano, Kazuki Uetsuki et al.

Accumulating evidence from human genetic studies implicates the pituitary adenylate cyclase-activating polypeptide (PACAP) gene as a risk factor for psychiatric disorders, including schizophrenia and stress-related diseases. Mice with homozygous disruption of the PACAP gene display profound behavioral and neurological abnormalities that are ameliorated with the atypical antipsychotic and...

DOI: 10.1371/journal.pone.0089153 Full text