Comparison of R-ketamine and rapastinel antidepressant effects in the social defeat stress model of depression
Psychopharmacology August 3, 2016 Bangkun Yang, Ji-Chun Zhang, Mei Han et al. 93 citations
RATIONALE: The N-methyl-D-aspartate (NMDA) receptor antagonists, including R-ketamine and rapastinel (formerly GLYX-13), show rapid antidepressant effects in animal models of depression. OBJECTIVE: We compared the rapid and sustained antidepressant effects of R-ketamine and rapastinel in the social defeat stress model. RESULTS: In the tail suspension and forced swimming tests, R-ketamine (10...