Molecular, haemodynamic and functional effects of LSD in the human brain
medRxiv June 18, 2025 Drummond E-Wen Mcculloch, Kristian Larsen, Annette Johansen et al. preprint
In this study, we provide the first study to integrate molecular and functional neuroimaging during psychedelic drug effects in humans. Using simultaneous PET-MRI technology, we describe multiple brain actions of lysergic acid diethylamide (LSD) in healthy volunteers. We quantify the occupancy of LSD at cerebral serotonin 2A receptors and show that LSD increases global cerebral blood flow and...