Tolerance and cross-tolerance to neurocognitive effects of THC and alcohol in heavy cannabis users
Psychopharmacology October 30, 2010 Johannes G. Ramaekers, Eef L. Theunissen, Marjolein de Brouwer et al. 168 citations
INTRODUCTION: Previous research has shown that heavy cannabis users develop tolerance to the impairing effects of Δ9-tetrahydrocannabinol (THC) on neurocognitive functions. Animal studies suggest that chronic cannabis consumption may also produce cross-tolerance for the impairing effects of alcohol, but supportive data in humans is scarce. PURPOSE: The present study was designed to assess...