Nitrous oxide for late-life depression with inadequate antidepressant response: a randomised controlled trial.
EClinicalMedicine April 2, 2026 Antony Salamé, Samuel Bulteau, Gabriel Robert et al.
Background Late-life depression with inadequate antidepressant response is a pressing clinical issue with limited proven therapies. Nitrous oxide (N 2 O) may offer a new therapeutic avenue with rapid and safe antidepressant effects in late-life depression with inadequate antidepressant response. Methods We conducted a double-blind, randomised, placebo-controlled, single-dose trial (November...