Psilocybin selectively rescues cognitive flexibility impairments caused by aberrant prefrontal error signaling
bioRxiv July 9, 2026 Christine Liu, Ellie M. Ho, Alexander S. Enos et al.
Psychedelic drugs show remarkable potential for treating psychiatric disorders, but the mechanisms underlying their therapeutic effects remain relatively unknown. Here, we demonstrate that psilocybin can powerfully ameliorate deficits in cognitive flexibility, but this effect depends on the specific circuit-level cause of those deficits. Using optogenetic models of cognitive inflexibility in...