Trauma nightmares that closely replicate a real traumatic event are especially linked to next-day distress and suicidal thoughts, more so than other dream features. Subjective dream length, post-dream arousal, and distress severity also independently predict daytime symptoms. The findings highlight the value of measuring specific dream characteristics to understand nightmare effects and their connection to suicidal ideation, and support the use of mobile app sleep diaries for collecting detailed, real-time data.
Among trauma-exposed veterans and civilians, poor mood before bed increases the risk of having at least one distressing dream, which in turn leads to poor mood the following morning. That negative mood carries over into the next evening, further raising the risk of another distressing dream. Individuals with better emotion regulation have a lower incidence of distressing dreams and better mood on average, after adjusting for sex, age, and PTSD severity. The findings suggest that mood and distressing dreams form a bidirectional cycle, and that emotion regulation abilities may help mitigate this risk.
Patients with treatment-resistant depression whose symptoms are loosely connected before ketamine therapy are more likely to respond than those with tightly linked symptoms. Among 447 patients receiving intravenous ketamine or intranasal eskatamine, non-responders had denser pre-treatment symptom networks (global strength 4.03) compared with responders (global strength 1.06). After treatment, responders' network strength increased, while non-responders' decreased. Sparse baseline symptom networks may indicate greater capacity for reorganization, making pre-treatment network density a potential marker of ketamine response.