MDMA clinical trials: pipeline by phase and status
Every trial in this library's ClinicalTrials.gov slice that names MDMA: 115 registered studies, grouped by phase and by recruitment status. For the published research, see the MDMA research page.
The pipeline at a glance
| Phase | Trials |
|---|---|
| Early phase 1 | 10 |
| Phase 1 | 32 |
| Phase 1/2 | 3 |
| Phase 2 | 43 |
| Phase 2/3 | 1 |
| Phase 3 | 7 |
| Not applicable | 12 |
| Unspecified | 7 |
| Status | Trials |
|---|---|
| Recruiting or planned | 32 |
| Active, not recruiting | 2 |
| Completed | 66 |
| Stopped | 10 |
| Unknown or other | 5 |
5,056 participants across the 114 trials that report enrollment. The earliest registered start is 2001, and 30 trials started in the last two years.
Most active sponsors
- Resilient Pharmaceuticals 28 trials
- University Hospital, Basel, Switzerland 23 trials
- University of Chicago 7 trials
- California Pacific Medical Center Research Institute 2 trials
- Emory University 2 trials
Evidence by condition
All 115 trials
Most advanced phase first, and within each phase the most recent start date first.
Phase 3 7 trials
-
Active, not recruiting Phase 3 20 participants Healing Breakthrough Started 2024
Post-Traumatic Stress Disorder
-
Recruiting Phase 3 60 participants Herzog Hospital Started 2024
PTSD, Post Traumatic Stress Disorder, Moral Injury
-
Completed Phase 3 16 participants Dr. Leslie Morland Started 2023
PTSD, Relational Problems
-
Completed Phase 3 87 participants Resilient Pharmaceuticals Started 2021
PTSD
-
Completed Phase 3 121 participants Resilient Pharmaceuticals Started 2020
Posttraumatic Stress Disorder
-
Completed Phase 3 100 participants Resilient Pharmaceuticals Started 2018
Posttraumatic Stress Disorder
-
Completed Phase 3 45 participants University of Southern California Started 2018
PTSD
Phase 2/3 1 trial
-
Recruiting Phase 2/3 80 participants VA Office of Research and Development Started 2026
Post Traumatic Stress Disorder, Alcohol Use Disorder
Phase 2 43 trials
-
Not yet recruiting Phase 2 15 participants Jenna M. Traynor Started 2026
Posttraumatic Stress Disorder (PTSD)
-
Not yet recruiting Phase 2 86 participants U.S. Army Medical Research and Development Command Started 2026
PTSD, Post Traumatic Stress Disorder PTSD, Post Traumatic Stress Disorder
-
Not yet recruiting Phase 2 30 participants Nautilus Sanctuary Started 2026
Post-Traumatic Stress Disorder, Adjustment Disorders
-
Recruiting Phase 2 200 participants Emory University Started 2026
Post Traumatic Stress Disorder
-
Recruiting Phase 2 52 participants Sunstone Medical Started 2026
Post Traumatic Stress Disorder
-
Withdrawn Phase 2 0 participants Resilient Pharmaceuticals Started 2026
Anorexia Nervosa Restricting Type, Binge-Eating Disorder
-
Recruiting Phase 2 50 participants Unity Health Toronto Started 2026
Chronic Neuropathic Pain
-
Recruiting Phase 2 168 participants Sheba Medical Center Started 2025
PTSD
-
Recruiting Phase 2 20 participants Definium Therapeutics US, Inc. Started 2025
Autism Spectrum Disorder, ASD
-
Recruiting Phase 2 40 participants Carolyn Rodriguez Started 2025
Obsessive-Compulsive Disorder
-
Recruiting Phase 2 10 participants Yale University Started 2025
Borderline Personality Disorder
-
Withdrawn Phase 2 0 participants University of California, Los Angeles Started 2025
PTSD, Post Traumatic Stress Disorder, Adolescents, Psychotherapy
-
Recruiting Phase 2 60 participants Bronx VA Medical Center Started 2025
Posttraumatic Stress Disorder
-
Enrolling by invitation Phase 2 20 participants ARQ National Psychotrauma Centre Started 2025
Posttraumatic Stress Disorder (PTSD)
-
Recruiting Phase 2 40 participants Stephen Robert Marder Started 2025
Post Traumatic Stress Disorder
-
Recruiting Phase 2 30 participants Patricia Suppes Started 2025
PTSD
-
Recruiting Phase 2 60 participants Remedy Started 2024
Post Traumatic Stress Disorder
-
Recruiting Phase 2 15 participants University of New Mexico Started 2024
Stress Disorders, Post-Traumatic, Opioid Use Disorder
-
Enrolling by invitation Phase 2 40 participants Emory University Started 2024
PTSD
-
Completed Phase 2 22 participants Carolina L Haass-Koffler Started 2024
Alcohol Use Disorder, Post Traumatic Stress Disorder
-
Unknown status Phase 2 120 participants University of Sydney Started 2023
PTSD, Alcohol Use Disorder, Alcohol Dependence, Post-traumatic Stress Disorder
-
Withdrawn Phase 2 0 participants Resilient Pharmaceuticals Started 2023
PTSD
-
Recruiting Phase 2 60 participants Guy Schusheim Started 2023
Post Traumatic Stress Disorder, MDMA ('Ecstasy')
-
Recruiting Phase 2 20 participants Sunstone Medical Started 2022
Cancer, Adjustment Disorders
-
Withdrawn Phase 2 0 participants Resilient Pharmaceuticals Started 2022
Posttraumatic Stress Disorder
-
Completed Phase 2 90 participants Jason B Luoma Started 2022
Social Anxiety Disorder
-
Terminated Phase 2 26 participants Resilient Pharmaceuticals Started 2021
PTSD
-
Completed Phase 2 10 participants Remedy Started 2021
Post Traumatic Stress Disorder
-
Completed Phase 2 5 participants VA Loma Linda Health Care System Started 2021
Post Traumatic Stress Disorder, Combat Stress Disorders
-
Completed Phase 2 21 participants MAPS Europe B.V. Started 2020
PTSD
-
Completed Phase 2 4 participants Resilient Pharmaceuticals Started 2018
Posttraumatic Stress Disorder
-
Completed Phase 2 38 participants Resilient Pharmaceuticals Started 2017
PTSD
-
Completed Phase 2 18 participants Resilient Pharmaceuticals Started 2015
Anxiety
-
Terminated Phase 2 6 participants Resilient Pharmaceuticals Started 2014
Posttraumatic Stress Disorder
-
Completed Phase 2 12 participants Resilient Pharmaceuticals Started 2014
Social Anxiety in Autistic Adults
-
Completed Phase 2 29 participants Resilient Pharmaceuticals Started 2013
Posttraumatic Stress Disorder
-
Completed Phase 2 10 participants Resilient Pharmaceuticals Started 2013
Posttraumatic Stress Disorder (PTSD)
-
Completed Phase 2 3 participants Resilient Pharmaceuticals Started 2010
Posttraumatic Stress Disorder
-
Completed Phase 2 26 participants Resilient Pharmaceuticals Started 2010
Posttraumatic Stress Disorder
-
Terminated Phase 2 5 participants Resilient Pharmaceuticals Started 2007
Posttraumatic Stress Disorder
-
Terminated Phase 2 2 participants Brigham and Women's Hospital Started 2007
Anxiety Disorder, Cancer
-
Completed Phase 2 14 participants Resilient Pharmaceuticals Started 2006
Posttraumatic Stress Disorder
-
Completed Phase 2 23 participants Resilient Pharmaceuticals Started 2004
Posttraumatic Stress Disorder
Phase 1/2 3 trials
-
Recruiting Phase 1/2 20 participants Anya Bershad, MD, PhD Started 2024
Schizophrenia
-
Completed Phase 1/2 23 participants Portland VA Research Foundation, Inc Started 2023
PTSD
-
Completed Phase 1/2 12 participants Resilient Pharmaceuticals Started 2016
Posttraumatic Stress Disorder
Phase 1 32 trials
-
Recruiting Phase 1 40 participants Icahn School of Medicine at Mount Sinai Started 2026
Bulimia Nervosa
-
Not yet recruiting Phase 1 16 participants Resilient Pharmaceuticals Started 2026
Pharmacokinetics, Hepatic Impairment
-
Recruiting Phase 1 20 participants University Hospital, Basel, Switzerland Started 2026
Healhty
-
Recruiting Phase 1 30 participants Rachel Yehuda Started 2026
Mental Wellbeing
-
Recruiting Phase 1 40 participants Johns Hopkins University Started 2025
Posttraumatic Stress Disorder
-
Completed Phase 1 26 participants University Hospital, Basel, Switzerland Started 2025
Healthy
-
Completed Phase 1 24 participants University Hospital, Basel, Switzerland Started 2025
Healthy
-
Recruiting Phase 1 50 participants Johns Hopkins University Started 2025
Psychedelic Effects in Healthy Volunteers
-
Withdrawn Phase 1 0 participants Resilient Pharmaceuticals Started 2024
Psychological Effects of Study Drug
-
Withdrawn Phase 1 0 participants Yale University Started 2024
Post Traumatic Stress Disorder
-
Completed Phase 1 25 participants University Hospital, Basel, Switzerland Started 2023
Healthy
-
Completed Phase 1 122 participants University of Zurich Started 2023
Healthy
-
Completed Phase 1 24 participants University Hospital, Basel, Switzerland Started 2023
Healthy
-
Completed Phase 1 24 participants University Hospital, Basel, Switzerland Started 2022
Healthy
-
Completed Phase 1 14 participants Resilient Pharmaceuticals Started 2022
Pharmacokinetics
-
Unknown status Phase 1 17 participants Germans Trias i Pujol Hospital Started 2021
Substance Use, Healthy Subjects
-
Completed Phase 1 23 participants University Hospital, Basel, Switzerland Started 2021
Healthy
-
Completed Phase 1 24 participants University Hospital, Basel, Switzerland Started 2021
Healthy
-
Unknown status Phase 1 20 participants Imperial College London Started 2018
Alcohol Use Disorder
-
Completed Phase 1 34 participants Resilient Pharmaceuticals Started 2017
Startle Response
-
Completed Phase 1 36 participants University of Chicago Started 2016
Healthy, MDMA ('Ecstasy')
-
Completed Phase 1 12 participants Parc de Salut Mar Started 2014
Amphetamine-Related Disorders
-
Completed Phase 1 16 participants University Hospital, Basel, Switzerland Started 2013
Healthy, Substance-related Disorders
-
Completed Phase 1 16 participants University Hospital, Basel, Switzerland Started 2011
Healthy
-
Completed Phase 1 16 participants University Hospital, Basel, Switzerland Started 2011
Mood Disorder, Substance-Related Disorders, Amphetamine-Related Disorders
-
Completed Phase 1 107 participants Resilient Pharmaceuticals Started 2011
Psychological Effects of Study Drug
-
Completed Phase 1 16 participants University Hospital, Basel, Switzerland Started 2010
Mood Disorder, Substance-Related Disorders, Amphetamine-Related Disorders
-
Completed Phase 1 16 participants University Hospital, Basel, Switzerland Started 2009
Mood Disorder, Substance-Related Disorders, Amphetamine-Related Disorders
-
Completed Phase 1 16 participants University Hospital, Basel, Switzerland Started 2009
Mood Disorder, Substance-related Disorders, Amphetamine-related Disorders
-
Completed Phase 1 187 participants National Institute on Drug Abuse (NIDA) Started 2004
Substance-Related Disorders
-
Completed Phase 1 27 participants Parc de Salut Mar Started 2003
Metabolism, Interaction
-
Completed Phase 1 16 participants University Hospital, Basel, Switzerland Started 2001
Mood Disorder, Substance-Related Disorders, Amphetamine-Related Disorders
Early phase 1 10 trials
-
Recruiting Early Phase 1 20 participants Spaulding Rehabilitation Hospital Started 2026
Fibromyalgia
-
Active, not recruiting Early Phase 1 12 participants University of Washington Started 2024
Narcissism
-
Completed Early Phase 1 33 participants University of Chicago Started 2023
MDMA ('Ecstasy'), Social Interaction
-
Completed Early Phase 1 43 participants University of Chicago Started 2022
Stimulant Use, MDMA ('Ecstasy'), Social Behavior, Motivation
-
Completed Early Phase 1 30 participants University of Chicago Started 2021
Interaction, Social
-
Completed Early Phase 1 30 participants University Hospital, Basel, Switzerland Started 2019
Healthy
-
Completed Early Phase 1 22 participants University of Chicago Started 2019
Autism Spectrum Disorder, Healthy
-
Completed Early Phase 1 28 participants University Hospital, Basel, Switzerland Started 2017
Healthy
-
Completed Early Phase 1 24 participants University Hospital, Basel, Switzerland Started 2013
Healthy, Substance-related Disorder, Mood Disorder
-
Completed Early Phase 1 30 participants University Hospital, Basel, Switzerland Started 2012
Social Cognition
Not applicable 12 trials
-
Not yet recruiting 40 participants University Hospital, Basel, Switzerland Started 2026
Autism Spectrum Disorder
-
Recruiting 24 participants University Hospital, Basel, Switzerland Started 2025
Central Diabetes Insipidus
-
Enrolling by invitation 48 participants Felix Mueller Started 2022
Personal Experience of Substance-assisted Therapy Using Psilocybin, MDMA, and LSD
-
Unknown status 200 participants Apollo Neuroscience, Inc. Started 2021
Stress Disorders, Post-Traumatic
-
Completed 30 participants University Hospital, Basel, Switzerland Started 2021
Diabetes Insipidus
-
Completed 759 participants Indiana University Started 2018
Mental Health Wellness 1, Happiness, Depression, Consciousness, Level Altered
-
Completed 84 participants University of Chicago Started 2014
Healthy
-
Completed 16 participants University Hospital, Basel, Switzerland Started 2011
Mood Disorder, Substance-Related Disorders, Amphetamine-Related Disorders
-
Completed 65 participants University of Chicago Started 2010
Drug Addiction
-
Completed 12 participants California Pacific Medical Center Research Institute Started 2010
MDMA Discontinuation Syndrome
-
Completed 13 participants California Pacific Medical Center Research Institute Started 2009
MDMA Mechanism of Action
-
Completed 50 participants University of Zurich Started 2006
Amphetamine-Related Disorders, Amphetamine Abuse
Unspecified 7 trials
-
Completed 30 participants Albany Research Institute, Inc. Started 2022
Post Traumatic Stress Disorder
-
Completed 22 participants Stanford University Started 2021
Healthy
-
Completed 186 participants Resilient Pharmaceuticals Started 2021
PTSD
-
Completed 10 participants Resilient Pharmaceuticals Started 2014
Posttraumatic Stress Disorder
-
Completed 39 participants Utrecht Institute for Pharmaceutical Sciences Started 2010
Hangover
-
Completed 18 participants Hadassah Medical Organization Started 2006
Amphetamine-Related Disorders
-
No longer available Resilient Pharmaceuticals
Post Traumatic Stress Disorder
Data from ClinicalTrials.gov (opens in new tab), refreshed daily. Browse all clinical trials.