DMT clinical trials: pipeline by phase and status
Every trial in this library's ClinicalTrials.gov slice that names DMT: 70 registered studies, grouped by phase and by recruitment status. For the published research, see the DMT research page.
The pipeline at a glance
| Phase | Trials |
|---|---|
| Early phase 1 | 2 |
| Phase 1 | 23 |
| Phase 1/2 | 4 |
| Phase 2 | 6 |
| Phase 3 | 7 |
| Phase 4 | 4 |
| Not applicable | 12 |
| Unspecified | 12 |
| Status | Trials |
|---|---|
| Recruiting or planned | 12 |
| Active, not recruiting | 7 |
| Completed | 43 |
| Stopped | 4 |
| Unknown or other | 4 |
17,150 participants across the 70 trials that report enrollment. The earliest registered start is 2006, and 17 trials started in the last two years.
Most active sponsors
- University Hospital, Basel, Switzerland 7 trials
- GH Research Ireland Limited 6 trials
- Novartis Pharmaceuticals 6 trials
- Biomind Labs Inc. 3 trials
- Universidade Federal do Rio Grande do Norte 3 trials
Evidence by condition
All 70 trials
Most advanced phase first, and within each phase the most recent start date first.
Phase 4 4 trials
-
Active, not recruiting Phase 4 136 participants Novartis Pharmaceuticals Started 2022
Relapsing-Remitting Multiple Sclerosis
-
Completed Phase 4 36 participants Biogen Started 2015
Multiple Sclerosis, Relapsing-Remitting
-
Completed Phase 4 61 participants Novartis Pharmaceuticals Started 2011
Relapsing Remitting Multiple Sclerosis
-
Completed Phase 4 1,053 participants Novartis Pharmaceuticals Started 2010
Relapsing Forms of Multiple Sclerosis
Phase 3 7 trials
-
Not yet recruiting Phase 3 200 participants University Hospital, Strasbourg, France Started 2025
Relapsing-remitting Multiple Sclerosis (RRMS)
-
Completed Phase 3 185 participants Novartis Pharmaceuticals Started 2021
Multiple Sclerosis
-
Active, not recruiting Phase 3 250 participants Rennes University Hospital Started 2019
Multiple Sclerosis
-
Terminated Phase 3 16 participants Genzyme, a Sanofi Company Started 2017
Multiple Sclerosis
-
Completed Phase 3 681 participants Hoffmann-La Roche Started 2016
Multiple Sclerosis, Relapsing-Remitting
-
Completed Phase 3 608 participants Genentech, Inc. Started 2016
Multiple Sclerosis, Relapsing-Remitting
-
Completed Phase 3 202 participants University Health Network, Toronto Started 2006
Bone Density, Osteopenia, Osteoporosis, Post-Menopause
Phase 2 6 trials
-
Recruiting Phase 2 140 participants Universidade Federal do Rio Grande do Norte Started 2026
MDD, Major Depressive Disorder (MDD), Major Depression, Suicidal Ideation
-
Not yet recruiting Phase 2 80 participants Sichuan Academy of Medical Sciences Started 2026
Multiple Sclerosis (MS) Relapsing Remitting
-
Withdrawn Phase 2 0 participants Johns Hopkins University Started 2025
PTSD - Post Traumatic Stress Disorder, Cognitive Dysfunction, Brain Trauma, Brain Injuries
-
Completed Phase 2 36 participants Cybin IRL Limited Started 2024
Generalized Anxiety Disorder
-
Completed Phase 2 14 participants Universidade Federal do Rio Grande do Norte Started 2023
Depressive Disorder, Depression, Unipolar
-
Terminated Phase 2 263 participants Biogen Started 2017
Multiple Sclerosis
Phase 1/2 4 trials
-
Completed Phase 1/2 20 participants Biomind Labs Inc. Started 2024
Mild Cognitive Impairment, Anxiety State, Depression Anxiety Disorder
-
Completed Phase 1/2 40 participants Biomind Labs Inc. Started 2024
Healthy Volunteers
-
Completed Phase 1/2 66 participants Small Pharma Ltd Started 2021
Major Depressive Disorder
-
Completed Phase 1/2 16 participants GH Research Ireland Limited Started 2019
Treatment Resistant Depression, Major Depressive Disorder, Depression
Phase 1 23 trials
-
Not yet recruiting Phase 1 20 participants Jon Dean Started 2026
Healthy Participants Study
-
Recruiting Phase 1 40 participants University Hospital, Basel, Switzerland Started 2026
5-methoxy-dimethyltryptamine (5-MeO-DMT)
-
Completed Phase 1 13 participants GH Research Ireland Limited Started 2026
Healthy Adult
-
Recruiting Phase 1 63 participants Yale University Started 2025
Alcohol Use Disorder (AUD), Alcohol-Related Disorders, Alcohol Use
-
Recruiting Phase 1 24 participants University Hospital, Basel, Switzerland Started 2025
Healthy
-
Recruiting Phase 1 60 participants Deepak C. D'Souza Started 2025
Major Depression Disorder, Depression
-
Recruiting Phase 1 50 participants Johns Hopkins University Started 2025
Psychedelic Effects in Healthy Volunteers
-
Completed Phase 1 17 participants University Hospital, Basel, Switzerland Started 2025
Healthy
-
Terminated Phase 1 71 participants GH Research Ireland Limited Started 2024
Healthy Volunteers
-
Completed Phase 1 36 participants University Hospital, Basel, Switzerland Started 2024
Healthy
-
Completed Phase 1 17 participants Insel Gruppe AG, University Hospital Bern Started 2024
Neuropharmacological Investigation of Ayahuasca Constituents DMT and Harmine
-
Completed Phase 1 16 participants Reconnect Labs Started 2023
Healthy
-
Completed Phase 1 25 participants Universidade Federal do Rio Grande do Norte Started 2023
Safety Issues, Healthy Volunteers
-
Active, not recruiting Phase 1 60 participants Algernon Pharmaceuticals Started 2023
Stroke
-
Completed Phase 1 54 participants Usona Institute Started 2022
Pharmacokinetics, Safety, Tolerability
-
Completed Phase 1 64 participants GH Research Ireland Limited Started 2022
Healthy Volunteers
-
Completed Phase 1 24 participants University Hospital, Basel, Switzerland Started 2022
Healthy
-
Completed Phase 1 27 participants Biomind Labs Inc. Started 2022
Healthy Volunteers
-
Completed Phase 1 36 participants Beckley Psytech Limited Started 2021
Pharmacokinetics in Healthy Adults
-
Completed Phase 1 46 participants GH Research Ireland Limited Started 2021
Healthy Volunteers
-
Completed Phase 1 31 participants University Hospital, Basel, Switzerland Started 2021
Healthy
-
Active, not recruiting Phase 1 30 participants Yale University Started 2021
Major Depressive Disorder, Depression
-
Completed Phase 1 22 participants GH Research Ireland Limited Started 2019
Healthy Volunteers
Early phase 1 2 trials
-
Completed Early Phase 1 40 participants Milan Scheidegger Started 2023
Healthy Participants
-
Completed Early Phase 1 34 participants Psychiatric University Hospital, Zurich Started 2020
Emotions, Mood, Cognitive Function 1, Social, Empathy
Not applicable 12 trials
-
Not yet recruiting 96 participants Universiti Putra Malaysia Started 2026
Autism Spectrum Disorder (ASD)
-
Recruiting 112 participants University Hospital, Basel, Switzerland Started 2025
Major Depressive Disorder, Psychedelic Experiences
-
Completed 8 participants University of Erlangen-Nürnberg Medical School Started 2025
Cancer Patients and Physical Activity
-
Unknown status 411 participants Max Nieuwdorp Started 2023
Upper Respiratory Tract Infection
-
Completed 61 participants University of Haifa Started 2023
Older Adults
-
Completed 30 participants Amasya University Started 2022
Schizophrenia, Negative Symptoms in Schizophrenia, Disabilities Mental, Dance Therapy
-
Completed 135 participants The University of Hong Kong Started 2021
Depression in Old Age
-
Unknown status 130 participants Amsterdam UMC, location VUmc Started 2020
Multiple Sclerosis, Multiple Sclerosis, Relapsing-Remitting, Multiple Sclerosis, Secondary Progressive
-
Completed 66 participants Drexel University Started 2019
Chronic Low-back Pain
-
Completed 75 participants Centre de Recherche de l'Institut Universitaire de Geriatrie de Montreal Started 2015
Aging
-
Unknown status 24 participants Shalvata Mental Health Center Started 2015
Anxiety Disorders
-
Completed 46 participants University of Utah Started 2008
Premature Birth of Newborn
Unspecified 12 trials
-
Recruiting 2,000 participants Imperial College London Started 2026
Multiple Sclerosis, Multiple Sclerosis (MS) - Relapsing-remitting, Multiple Sclerosis (MS) Primary Progressive
-
Active, not recruiting 519 participants Novartis Pharmaceuticals Started 2024
Multiple Sclerosis
-
Completed 104 participants Bristol-Myers Squibb Started 2023
Multiple Sclerosis, Relapsing-Remitting
-
Completed 3,632 participants Novartis Started 2023
Multiple Sclerosis
-
Completed 39 participants Novartis Pharmaceuticals Started 2023
Multiple Sclerosis
-
Active, not recruiting 52 participants Axial Therapeutic Research Started 2022
PTSD - Post Traumatic Stress Disorder, Cognitive Dysfunction, Brain Injury, Depression - Major Depressive Disorder
-
Completed 76 participants University of Colorado, Denver Started 2021
Multiple Sclerosis
-
Active, not recruiting 2,961 participants Bristol-Myers Squibb Started 2021
Multiple Sclerosis
-
Unknown status 323 participants Monash University Started 2020
Multiple Sclerosis, Adherence, Medication
-
Completed 32 participants Delphinus Medical Technologies, Inc. Started 2020
Breast Cancer Detection, Dense Breast Parenchyma, Benign Breast Findings, Normal Breast Screening
-
Completed 650 participants University Hospital, Caen Started 2017
C10.114.375.500
-
Completed 545 participants Merck KGaA, Darmstadt, Germany Started 2012
Relapsing Multiple Sclerosis
Data from ClinicalTrials.gov (opens in new tab), refreshed daily. Browse all clinical trials.