5-MeO-DMT clinical trials: pipeline by phase and status
Every trial in this library's ClinicalTrials.gov slice that names 5-MeO-DMT: 20 registered studies, grouped by phase and by recruitment status. For the published research, see the 5-MeO-DMT research page.
The pipeline at a glance
| Phase | Trials |
|---|---|
| Early phase 1 | 1 |
| Phase 1 | 11 |
| Phase 1/2 | 2 |
| Phase 2 | 4 |
| Not applicable | 1 |
| Unspecified | 1 |
| Status | Trials |
|---|---|
| Recruiting or planned | 5 |
| Active, not recruiting | 2 |
| Completed | 12 |
| Stopped | 1 |
850 participants across the 20 trials that report enrollment. The earliest registered start is 2020, and 7 trials started in the last two years.
Most active sponsors
- University Hospital, Basel, Switzerland 4 trials
- Biomind Labs Inc. 3 trials
- Universidade Federal do Rio Grande do Norte 3 trials
- Algernon Pharmaceuticals 1 trial
- Axial Therapeutic Research 1 trial
All 20 trials
Most advanced phase first, and within each phase the most recent start date first.
Phase 2 4 trials
-
Recruiting Phase 2 140 participants Universidade Federal do Rio Grande do Norte Started 2026
MDD, Major Depressive Disorder (MDD), Major Depression, Suicidal Ideation
-
Withdrawn Phase 2 0 participants Johns Hopkins University Started 2025
PTSD - Post Traumatic Stress Disorder, Cognitive Dysfunction, Brain Trauma, Brain Injuries
-
Completed Phase 2 36 participants Cybin IRL Limited Started 2024
Generalized Anxiety Disorder
-
Completed Phase 2 14 participants Universidade Federal do Rio Grande do Norte Started 2023
Depressive Disorder, Depression, Unipolar
Phase 1/2 2 trials
-
Completed Phase 1/2 20 participants Biomind Labs Inc. Started 2024
Mild Cognitive Impairment, Anxiety State, Depression Anxiety Disorder
-
Completed Phase 1/2 40 participants Biomind Labs Inc. Started 2024
Healthy Volunteers
Phase 1 11 trials
-
Not yet recruiting Phase 1 20 participants Jon Dean Started 2026
Healthy Participants Study
-
Recruiting Phase 1 40 participants University Hospital, Basel, Switzerland Started 2026
5-methoxy-dimethyltryptamine (5-MeO-DMT)
-
Recruiting Phase 1 63 participants Yale University Started 2025
Alcohol Use Disorder (AUD), Alcohol-Related Disorders, Alcohol Use
-
Completed Phase 1 36 participants University Hospital, Basel, Switzerland Started 2024
Healthy
-
Completed Phase 1 17 participants Insel Gruppe AG, University Hospital Bern Started 2024
Neuropharmacological Investigation of Ayahuasca Constituents DMT and Harmine
-
Completed Phase 1 25 participants Universidade Federal do Rio Grande do Norte Started 2023
Safety Issues, Healthy Volunteers
-
Active, not recruiting Phase 1 60 participants Algernon Pharmaceuticals Started 2023
Stroke
-
Completed Phase 1 54 participants Usona Institute Started 2022
Pharmacokinetics, Safety, Tolerability
-
Completed Phase 1 24 participants University Hospital, Basel, Switzerland Started 2022
Healthy
-
Completed Phase 1 27 participants Biomind Labs Inc. Started 2022
Healthy Volunteers
-
Completed Phase 1 36 participants Beckley Psytech Limited Started 2021
Pharmacokinetics in Healthy Adults
Early phase 1 1 trial
-
Completed Early Phase 1 34 participants Psychiatric University Hospital, Zurich Started 2020
Emotions, Mood, Cognitive Function 1, Social, Empathy
Not applicable 1 trial
-
Recruiting 112 participants University Hospital, Basel, Switzerland Started 2025
Major Depressive Disorder, Psychedelic Experiences
Unspecified 1 trial
-
Active, not recruiting 52 participants Axial Therapeutic Research Started 2022
PTSD - Post Traumatic Stress Disorder, Cognitive Dysfunction, Brain Injury, Depression - Major Depressive Disorder
Data from ClinicalTrials.gov (opens in new tab), refreshed daily. Browse all clinical trials.