Increased effects of 3,4-methylenedioxymethamphetamine (ecstasy) in a rat model of depression.
Addict Biol 2011
Increased effects of 3,4-methylenedioxymethamphetamine (ecstasy) in a rat model of depression.
MDMA for depression: all studies
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Research
Ecstasy (MDMA) and its Relationship with Self- Report Depression, Anxiety and Schizotypy
Clínica y Salud 2010 Lisa Wood, Barkus Emma 1 citation
Aims: The relationship between ecstasy and affective psychological symptoms are still subject to debate. We aimed to examine the relationship between Ecstasy use and self-report depression, anxiety and schizotypy. Design: Data were collected via structured remote self-report questionnaires. Participants: Participants were split into three groups: a control group with no ecstasy use, a light...
Major depression: the relative contribution of gender, MDMA, and cannabis use
Depression and Anxiety March 7, 2007 Heather Durdle, Leslie H. Lundahl, Chris‐ellyn Johanson et al. 34 citations
Previous research has suggested that 3,4-methylenedioxymethamphetamine (MDMA; ecstasy) users have elevated depressive symptomatology, although it is not clear whether this is due to MDMA or other drug use. This study aimed to investigate the contributions of MDMA and cannabis use to Major Depressive Disorder in MDMA users. A total of 226 MDMA users were studied. Participants (65% male) reported...
Electroconvulsive therapy in the treatment of depression in a former ecstasy user
Journal of Psychopharmacology November 1, 2006 Roland W. Freudenmann, Carlos Schönfeldt-lecuona, Manfred Spitzer et al. 4 citations
Depression in former ecstasy users may not respond to selective serotonin reuptake inhibitors (SSRIs) possibly due to damaged serotonergic synapses following long-term heavy ecstasy use. We report findings in a patient suffering from MDMA-induced depression which was refractory to several antidepressive medications including selective noradrenergic reuptake inhibitor (SNRI) and SSRI. An add-on...
Recreational ecstasy use and depression.
Journal of psychopharmacology (Oxford, England) May 2006 Casey R. Guillot, David Greenway
Research in laboratory animals has shown that 3,4-methylenedioxymethamphetamine (MDMA or ecstasy) destroys serotonergic axons in the brain at certain doses. Serotonin is known to take part in the regulation of mood in humans. Many researchers have hypothesized that if recreational ecstasy use destroys serotonergic axons, then a corresponding decline in the mood of ecstasy users should be seen....
Symptoms of anxiety and depression in childhood and use of MDMA: prospective, population based study
BMJ February 24, 2006 Anja C. Huizink, Robert F Ferdinand, Jan Van der Ende et al. 77 citations
OBJECTIVE: To investigate whether using ecstasy (3,4-methylenedioxymethamphetamine, MDMA) is preceded by symptoms of behavioural and emotional problems in childhood and early adolescence. DESIGN: Prospective, longitudinal, population based study SETTING: The Dutch province of Zuid-Holland. PARTICIPANTS: A sample of 1580 individuals, followed up across a 14 year period, from childhood into...
Relationship between ecstasy use and depression: a study controlling for poly-drug use.
Psychopharmacology May 2004 Jonathan P. Roiser, Barbara J. Sahakian
3,4-Methylenedioxymethamphetamine (MDMA or "ecstasy") causes serotonin neuron damage in laboratory animals. The serotonin system is known to be important in the regulation of mood. Previous research has shown that MDMA users score higher on self-report ratings of depression than controls. However, MDMA users commonly take other illicit substances and many studies do not fully control for...
MDMA Assisted Psychotherapy Decreases PTSD Symptoms, Dissociation, Functional Disability, and Depression: A Systematic Review and Meta-Analysis
medRxiv Warwick M. Green, Sanket B Raut, F.l.j. James et al. 4 citations preprint
Abstract Post-Traumatic Stress Disorder (PTSD) causes broad impairments affecting quality of life. However, despite current treatment many people with PTSD do not fully recover. MDMA assisted psychotherapy has emerged as a new therapy for PTSD and its comorbidities. We aimed to analyse the current evidence for MDMA assisted psychotherapy in PTSD and associated quality of life, and physiological...