Ketamine for anxiety: all studies (page 4)

Hope for Neurotic Disorders: A Summary of New Zealand Research on the Development of Biomarkers and Novel Treatments.

Journal of the Royal Society of New Zealand February 1, 2026 Neil McNaughton, Shabah M. Shadli, Ben Beaglehole et al.

The neurotic disorders (e.g., depression, dysthymia, generalized anxiety disorder, panic disorder, agoraphobia, social anxiety, post-traumatic stress disorder, and obsessive-compulsive disorder) are costly and difficult to treat. Diagnosis is based on symptoms not biological causes. Here, we summarize New Zealand-based work developing EEG biomarkers and novel treatments. Working at the...

DOI: 10.1002/snz2.70002 Full text Depression Ketamine EEG Anxiety biomarker +1

A retrospective report of a ketamine-augmented, transdiagnostic psychiatric outpatient psychotherapy program

Journal of Military, Veteran and Family Health February 1, 2026 Ian Stefanuk, Kaitlin Chivers-Wilson, Rakesh Jetly et al.

Introduction: Comorbid conditions such as major depressive disorder, anxiety disorders, and posttraumatic stress disorder are common among Veterans, and the presence of multiple conditions requires innovative treatment approaches. The Newly Institute in Calgary, Alberta, Canada, has introduced a novel intervention combining sublingual ketamine therapy with a medically managed transdiagnostic...

DOI: 10.3138/jmvfh-2025-0009 Anxiety disorder Checklist Depression economics Intervention counseling +7

Repeated 7-day exposure to ketamine induces anxiety-like behaviors and neuronal apoptosis in mice via DRD1-medicated inhibition of Akt/Gsk-3β phosphorylation.

Cell Biology and Toxicology January 30, 2026 Jia-Yi Wei, Peng Lv, Jiayu Zhang et al.

Repeated exposure to ketamine leads to mental behavioral disorders and cognitive deficits in mice. As a neurotransmitter receptor, dopamine receptor 1 (DRD1) is involved in mental regulation and memory formation. However, the role of DRD1 in ketamine's behavioral disorder and neurotoxicity remains unclear. We found that seven-day ketamine exposure induced anxiety-like, depressive-like behavior...

DOI: 10.1007/s10565-026-10149-4 Full text Anxiety-like behavior Apoptosis Drd1 Ketamine abuse

Symptom trajectories and clinical outcomes of intravenous ketamine in treatment-resistant depression: A real-world study using group-based trajectory modeling.

Journal of Affective Disorders January 23, 2026 Reinhard Janssen-Aguilar, Jithin Joseph, Huda Al-Shamali et al.

Intravenous (IV) ketamine is an emerging intervention for treatment-resistant depression (TRD), yet the temporal dynamics of response and the optimal number of infusions remain unclear, particularly in real-world clinical populations with psychiatric comorbidities. We conducted a retrospective chart review of 209 adults with TRD treated with IV ketamine at an interventional psychiatry program....

DOI: 10.1016/j.jad.2026.121230 Full text Anxiety Treatment-resistant depression Iv ketamine Real-world evidence +1

Ketamine assisted psychotherapy in postpartum mood and anxiety disorders: a limited case series

Frontiers in Psychiatry January 22, 2026 Alka Christnacht, Therry Rose J Eparwa, Emily Whinkin et al.

The postpartum period is notorious for rapid and profound changes for birthing individuals and their families. Significant shifts to hormonal and physical health, routines and family roles, and the salience of personal and community risk factors all contribute to potential psychiatric and psychological distress for parents, sometimes diagnosed as a postpartum mood or anxiety disorder (PMAD)....

DOI: 10.3389/fpsyt.2025.1661604 Anxiety Ketamine Distress Postpartum depression +8

AMELIORATIVE EFFECTS OF SELECTIVE PDE-10 INHIBITORS AGAINST KETAMINE-MEDIATED SCHIZOPHRENIC OUTCOMES IN MICE

Asian Journal of Pharmaceutical and Clinical Research January 7, 2026 Ruchika Srivastava, Prabhat Singh, Ajeet

Objectives: Schizophrenia (SCZ) is characterized by significant impairments in perception and cognitive flexibility. Making accurate plans for therapy demands a deeper comprehension of the brain mechanisms behind these disorders. The purpose of our investigation is to analyze the protective effects of papaverine, a phosphodiesterase-10 inhibitor, on ketamine-induced SCZ -like behavioral and...

DOI: 10.22159/ajpcr.2026v19i1.55825 Ketamine Anxiety Clozapine Open field +10

Investigation of Esketamine Administration During Surgical Procedures for the Alleviation of Postoperative Anxiety and Depression in Adolescent Patients: A Randomized Controlled Trial.

Drug Design, Development and Therapy 2026 Yanhong Li, Kuangyu Zhao, Peipei Cao et al.

Surgical stress can lead to postoperative anxiety and depression, especially in adolescents. These complications reduce quality of life and increase medical burdens, but perioperative psychological interventions for adolescents are limited, and related mechanisms remain unclear. Esketamine (S-ketamine), an N-methyl-D-aspartate receptor (NMDAR) antagonist, has analgesic, sedative,...

DOI: 10.2147/dddt.s587626 Full text S-ketamine Inflammatory markers Postoperative pain

Evaluating the potential risk of ketamine-induced hepatotoxicity in the treatment of mood and anxiety disorders: A systematic review.

General Hospital Psychiatry 2026 Gabrielle F. M. Lovell, Shreya Vasudeva, Diana Orsini et al.

Ketamine is a dissociative anesthetic with potential for treating mood, anxiety, and related disorders; however, concerns have emerged regarding hepatotoxicity in the context of chronic treatment. Systematic searches of PubMed, Scopus, and Ovid databases were conducted from inception to August 2025. Eligible studies included randomized controlled trials (RCTs), observational studies, and case...

DOI: 10.1016/j.genhosppsych.2026.04.005 Full text Esketamine Major depressive disorder Alanine aminotransferase Aspartate aminotransferase +2

Effects of esketamine on postoperative pain, anxiety, depression, sleep, and inflammation in pregnancies undergoing cesarean section: A randomized controlled trial.

PLoS One 2026 Yijun Wang, Xiaolu Lin, Xiang Zou et al.

Postoperative pain is the most notable issue after cesarean section (CS). The contributing factors include hyperalgesia, anxiety, depression, sleep disorders, and inflammation. In this study, we explored the effects of esketamine on pain, hyperalgesia, depression, anxiety, sleep disorders, and inflammation after CS. This randomized, blinded, controlled trial enrolled single-term pregnant women...

DOI: 10.1371/journal.pone.0328585 Full text

Ketamine attenuates anxiety-like behavior and oxidative imbalance in the maternal immune activation model: emphasis on the cerebellum.

Psychopharmacology November 28, 2025 Elifrances Galdino de Oliveira, Mayara Victória De Souza Barbosa, Diógenes Afonso De Lima et al.

Relevant to the study of neurodevelopmental disorders, maternal immune activation (MIA) models reproduce the high incidence of anxiety disorders and molecular alterations in the cerebellum reported in patients with schizophrenia and autism. In parallel, ketamine, a fast-acting antidepressant, has shown beneficial effects in psychiatric disorders with immune-related components. To investigate...

DOI: 10.1007/s00213-025-06974-w Full text Anxiety Ketamine Cerebellum Maternal immune activation +1