Advanced Delivery Systems and Novel Psilocin Derivatives for Enhanced Therapeutic Applications.
ACS Medicinal Chemistry Letters December 12, 2024 DOI: 10.1021/acsmedchemlett.4c00521 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Topics | Psilocybin |
| Keywords | Psychedelics Mental health treatment Pharmaceutical research Drug development |
| Key findings | Recent patents on controlled-release delivery systems, ester analogs, and acetal/ketal derivatives offer novel approaches to enhance the stability, bioavailability, and efficacy of psilocin and related psychedelic compounds. |
Abstract
Psychedelic compounds, particularly psilocybin and psilocin, have shown significant therapeutic potential in treating neurological and psychiatric disorders. However, their bioavailability, rapid metabolism, and stability challenges have limited their clinical use. This Patent Highlight reviews recent innovations in psychedelic drug delivery systems and the development of psilocin analogs aimed at improving their pharmacokinetic and pharmacodynamic profiles. Three patents-focused on controlled-release delivery systems, ester analogs, and acetal/ketal derivatives-present novel approaches to enhancing the stability, bioavailability, and efficacy of psilocin and related compounds. These advancements promise more effective treatments for conditions such as depression, chronic pain, and neurodegenerative diseases.
Comparable studies
Other narrative reviews on psilocybin, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Classic psychedelics: An integrative review of epidemiology, therapeutics, mystical experience, and brain network function. General population | 2019 | Integrative review | |
| The pharmacology of psilocybin | 2002 | Review | |
| Serotonin research: contributions to understanding psychoses | 2008 | Review | |
| Psychedelics, Meditation, and Self-Consciousness | 2018 | Review | |
| The abuse potential of medical psilocybin according to the 8 factors of the Controlled Substances Act | 2018 | Review |
Citations in the library
Cites 6
- Efficacy and safety of psychedelics for the treatment of mental disorders: A systematic review and meta-analysis. Psychiatry Research May 1, 2024
- Serotonergic Psychedelics: A Comparative Review of Efficacy, Safety, Pharmacokinetics, and Binding Profile Biological Psychiatry: Cognitive Neuroscience and Neuroimaging February 1, 2024
- Psilocybin and Other Classic Psychedelics in Depression. Current Topics in Behavioral Neurosciences 2024
- Psychedelics for alzheimer's disease-related dementia: Unveiling therapeutic possibilities and pathways Ageing Research Reviews February 1, 2024
- The Effects of Psychedelics on Neuronal Physiology. Annu Rev Physiol November 6, 2023
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